Technology Process of {1-[4-(3,4-dichloro-benzyloxy)-benzyl]-3,5-dimethyl-1H-pyrazol-4-yl}-acetic acid
There total 6 articles about {1-[4-(3,4-dichloro-benzyloxy)-benzyl]-3,5-dimethyl-1H-pyrazol-4-yl}-acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2.1: lithium aluminium tetrahydride; water / tetrahydrofuran / 3 h / 20 °C
3.1: phosphorus tribromide / dichloromethane; tert-butyl methyl ether / 2 h / 50 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
4.2: 3 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 4 h
With
lithium aluminium tetrahydride; water; phosphorus tribromide; sodium hydride; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride; water / tetrahydrofuran / 3 h / 20 °C
2.1: phosphorus tribromide / dichloromethane; tert-butyl methyl ether / 2 h / 50 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: 3 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 4 h
With
lithium aluminium tetrahydride; water; phosphorus tribromide; sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;
