N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide
• CAS No.: 940352-11-4
• Molecular Formula: C₂₁H₁₆ClN₃O₂S
• Molecular Weight: 409.896
• Mol file: 940352-11-4.mol

Synonyms:N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide

Chemical Property of N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide

There total 2 articles about N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-methyl-N-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]benzenesulfonamide (313495-66-8) → N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide (940352-11-4)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 2h; Heating;

DOI:10.1002/jccs.200700061 DOI:10.1515/znb-2006-0814

Reference yield:

2-[4-(toluene-4-sulfonylamino)benzoylamino]benzoic acid (37028-94-7) → N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide (940352-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / acetic anhydride / 3 h / Heating

2: 69 percent / ammonium acetate / 1 h / 160 - 170 °C

3: 73 percent / PCl₅; POCl₃ / 2 h / Heating

With ammonium acetate; phosphorus pentachloride; acetic anhydride; trichlorophosphate;

DOI:10.1002/jccs.200700061

Reference yield: 71.0%

N-[4-(4-chloroquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide (940352-11-4) + glycine (56-40-6,18875-39-3,25718-94-9) → {2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}-acetic acid (940352-22-7)

Guidance literature:

With sodium carbonate; at 100 ℃; for 8h; pH=9 - 9.5;

upstream raw materials:

4-methyl-N-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]benzenesulfonamide

2-[4-(toluene-4-sulfonylamino)benzoylamino]benzoic acid

Downstream raw materials:

N-[4-(4-hydrazinoquinazolin-2-yl)phenyl]-4-methylbenzenesulfonamide

2-oxo-2-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-yl}butyric acid ethyl ester

cyano-{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-yl}acetic acid ethyl ester

{2-[4-(toluene-4-sulfonylamino)phenyl]quinazolin-4-ylamino}-acetic acid