(Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one

Base Information

• Chemical Name: (Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one
• CAS No.: 288087-81-0
• Molecular Formula: C₁₀H₇Cl₄NO₂
• Molecular Weight: 314.983
• Mol file: 288087-81-0.mol

Synonyms:(Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one

Chemical Property of (Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one

There total 1 articles about (Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-chloro-2-hydroxyacetophenone (1450-74-4) + trichloroacetonitrile (545-06-2) → (Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one (288087-81-0)

Guidance literature:

With magnesium bromide-; In diethyl ether; at 20 ℃; for 3h;

DOI:10.1007/BF02494778

Reference yield: 77.0%

(Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one (288087-81-0) → 6-chloro-2-(trichloromethyl)-4H-chromen-4-one (133406-29-8)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 24h;

DOI:10.1007/BF02494778

Reference yield:

(Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one (288087-81-0) → 6-chloro-4-hydroxycoumarin (19484-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / conc. HCl / 24 h / 20 °C

2: 45 percent / KOH / methanol / 0.5 h / Heating

With hydrogenchloride; potassium hydroxide; In methanol; 1: Cyclization / 2: Hydrolysis;

DOI:10.1007/BF02494778

upstream raw materials:

5-chloro-2-hydroxyacetophenone

trichloroacetonitrile

Downstream raw materials:

6-chloro-2-(trichloromethyl)-4H-chromen-4-one

6-chloro-4-hydroxycoumarin