tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

Base Information

Chemical Name:tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate
CAS No.:257293-59-7
Molecular Formula:C₄₀H₄₃N₇O₃
Molecular Weight:669.827
Hs Code.:

Synonyms:tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

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Chemical Property of tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

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Technology Process of tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

There total 8 articles about tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 257293-60-0
2-benzyloxycarbonylamino-3-({1-[3-(1-trityl-1H-imidazol-2-ylamino)-propyl]-1H-indazole-5-carbonyl}-amino)-propionic acid tert-butyl ester

: 257293-59-7
tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

Guidance literature:: With hydrogen; 10percent Pd/C; In ethanol; for 5h; under 760.051 Torr;
DOI:10.1021/jm990049j

Reference yield:

: 77215-55-5
tert-butyl 2-N-carbobenzoxy-(S)-2,3-diaminopropionate

: 257293-59-7
tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

Guidance literature:: Multi-step reaction with 2 steps

1: DCC; HOBT / dimethylformamide / 24 h

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760.05 Torr

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 10percent Pd/C; In ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrogenolysis;
DOI:10.1021/jm990049j

Reference yield:

: 192944-51-7
1H-indazole-5-carboxylic acid ethyl ester

: 257293-59-7
tert-butyl 3-[1-[3-(N-triphenylmethylimidazol-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2(S)-aminopropionate

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / NaN(TMS)2; 18-crown-6 / tetrahydrofuran / 20 h / Heating

2: 98 percent / aq. HOAc / 20 h / 70 °C

3: toluene / 20 h / Heating

4: NaBH(OAc)3 / toluene / 20 h

5: 85 percent / 1.0 M aq. NaOH / ethanol / 4 h / Heating

6: DCC; HOBT / dimethylformamide / 24 h

7: H₂ / 10percent Pd/C / ethanol / 5 h / 760.05 Torr

With sodium hydroxide; 18-crown-6 ether; hydrogen; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; 10percent Pd/C; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: acidolysis / 3: Condensation / 4: Reduction / 5: Hydrolysis / 6: Condensation / 7: Hydrogenolysis;
DOI:10.1021/jm990049j