3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester

Base Information

• Chemical Name: 3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester
• CAS No.: 145232-14-0
• Molecular Formula: C₂₅H₃₀ClN₃O₆
• Molecular Weight: 503.983

Synonyms:3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester

Chemical Property of 3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester

Chemical Property:

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Technology Process of 3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester

There total 1 articles about 3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester (13798-75-9) + L-(4-chloro)Phe-NH2 (145232-15-1) → 3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester (145232-14-0)

Guidance literature:

In 1,2-dimethoxyethane; at 20 ℃;

DOI:10.1021/jm000937a

Reference yield:

3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester (145232-14-0) → BOC-Trp-L-3-(2-naphthyl)alanyl-Asp-(4-chloro)Phe-NH2

Guidance literature:

Multi-step reaction with 3 steps

1: TFA / 1 h

2: Et₃N / 1,2-dimethoxy-ethane / 20 °C

3: H₂ / 10percent Pd/C / methanol / 4 h

With hydrogen; triethylamine; trifluoroacetic acid; 10percent Pd/C; In methanol; 1,2-dimethoxyethane; 1: acidolysis / 2: amidation / 3: Hydrogenolysis;

DOI:10.1021/jm000937a

Reference yield:

3-tert-butoxycarbonylamino-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester (145232-14-0) → 3-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-naphthalen-2-yl-propionylamino}-N-[1-carbamoyl-2-(4-chloro-phenyl)-ethyl]-succinamic acid benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / 1 h

2: Et₃N / 1,2-dimethoxy-ethane / 20 °C

With triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; 1: acidolysis / 2: amidation;

DOI:10.1021/jm000937a

upstream raw materials:

N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

L-(4-chloro)Phe-NH₂

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