DIFUCOSYLLACTO-N-HEXAOSE (A)

Base Information

• Chemical Name: DIFUCOSYLLACTO-N-HEXAOSE (A)
• CAS No.: 64396-27-6
• Molecular Formula: C₅₂H₈₈N₂O₃₉
• Molecular Weight: 1365.26
• Mol file: 64396-27-6.mol

Synonyms:D-Glucose,O-6-deoxy-a-L-galactopyranosyl-(1®3)-O-[O-6-deoxy-a-L-galactopyranosyl-(1®3)-O-[b-D-galactopyranosyl-(1®4)]-O-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1®3)-b-D-galactopyranosyl-(1®4)]-O-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl-(1®3)-O-b-D-galactopyranosyl-(1®4)-; Difucosyl p-lacto-N-neohexaose

Chemical Property of DIFUCOSYLLACTO-N-HEXAOSE (A)

Chemical Property:

• PSA: 641.71000
• LogP: -15.32740
• Storage Temp.: −20°C

Purity/Quality:

HPLC＞90% ^*data from raw suppliers

Difucosyllacto-N-hexaose (a) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: B

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIFUCOSYLLACTO-N-HEXAOSE (A)

There total 3 articles about DIFUCOSYLLACTO-N-HEXAOSE (A) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C96H132N2O61 (118590-85-5,132201-00-4,132201-01-5) → Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glc (64396-27-6)

Guidance literature:

With sodium methylate; In methanol; for 48h; Ambient temperature;

Reference yield: 80.0%

guanosine 5’-diphospho-β-L-fucose (154235-70-8) + (β-D-galactopyranosyl)-(1->4)-(2-acetamido)-2-deoxy-β-D-glucopyranosyl)-(1->3)-(β-D-galactopyranosyl)-(1->4)-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1->3)-(β-D-galactopyranosyl)-(1->4)-α/β-D-glucopyranose → Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glc (64396-27-6)

Guidance literature:

With recombinant Helicobacter pylori α1–3-fucosyltransferase; FastAP; manganese(ll) chloride; In aq. buffer; at 37 ℃; pH=8; Enzymatic reaction;

DOI:10.1016/j.carres.2019.05.007

Reference yield:

Benzyl O-(2,6-Di-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranosyl)-(1->4)-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)>-(2-acetamido-6-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->3)-(2,6-di-O-benzyl-β-D-galactopyranosyl)-(1->4)-<(2,3,4-tri-..)> (132125-25-8) → Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glc (64396-27-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; acetic acid; for 24h; under 3750.3 Torr; Ambient temperature;

upstream raw materials:

Benzyl O-(2,6-Di-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranosyl)-(1->4)-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)>-(2-acetamido-6-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->3)-(2,6-di-O-benzyl-β-D-galactopyranosyl)-(1->4)-<(2,3,4-tri-..)>

C₉₆H₁₃₂N₂O₆₁

guanosine 5’-diphospho-β-L-fucose

Refernces

• 1、 Toepfer, Alexander,Kinzy, Willy,Schmidt, Richard R.. "Glycosyl Imidates, 65. Efficient Synthesis of the Lewis Antigen X (Lex) Family". . p. 449 - 464. Retrieved 2007/10/02.