(3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one

Base Information

• Chemical Name: (3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one
• CAS No.: 1434133-36-4
• Molecular Formula: C₂₀H₁₇F₂NO
• Molecular Weight: 325.358
• Mol file: 1434133-36-4.mol

Synonyms:(3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one

Chemical Property of (3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one

There total 2 articles about (3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

1-Methyl-4-piperidone (1445-73-4) + 2-Fluorobenzaldehyde (446-52-6) → (3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one (1434133-36-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 5 - 8 ℃;

DOI:10.1016/j.bmc.2013.03.057

Reference yield: 48.0%

1-Methyl-4-piperidone (1445-73-4) + 3-nitro-benzaldehyde (99-61-6) + 2-Fluorobenzaldehyde (446-52-6) → (3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one (1434133-36-4) + (3E,5E)-3–(2-fluorobenzylidene)-1-methyl-5-(3-nitrobenzylidene)piperidin-4-one + (3E,5E)-1-methyl-3,5-bis(3-nitrobenzylidene)piperidin-4-one (920030-44-0)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 2h; Green chemistry;

DOI:10.1016/j.ejmech.2018.01.088

Reference yield: 93.0%

(3E,5E)-3,5-bis(2-fluorobenzylidene)-1-methylpiperidin-4-one (1434133-36-4) + pipecolic Acid (4043-87-2,83680-83-5) + acenaphthene quinone (82-86-0) → spiro[2.2'']acenaphthene-1''-onespiro[3.3']-5'-(2-fluorophenylmethylidene)-1'-methylpiperidin-4'-one-4-(2-fluorophenyl)octahydroindolizine

Guidance literature:

In isopropyl alcohol; for 3h; stereoselective reaction; Reflux; Green chemistry;

DOI:10.1016/j.ejmech.2013.04.050

upstream raw materials:

1-Methyl-4-piperidone

2-Fluorobenzaldehyde

3-nitro-benzaldehyde