N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

Base Information

Chemical Name:N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide
CAS No.:1613639-15-8
Molecular Formula:C₂₃H₂₂FN₅O
Molecular Weight:403.459
Hs Code.:

Synonyms:N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

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Chemical Property of N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

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Technology Process of N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

There total 7 articles about N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613639-46-5
3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole

: 1613639-58-9
N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]propionamide

: 1613639-15-8
N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

Guidance literature:: With potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1613639-15-8
N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; L-proline; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; 2: |Mitsunobu Displacement;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613639-15-8
N-{(R)-2-[5-(3-fluoro-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethyl}propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; L-proline; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; 2: |Mitsunobu Displacement;