(S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Base Information

Chemical Name:(S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate
CAS No.:1445981-04-3
Molecular Formula:C₂HF₃O₂*C₂₁H₂₂Cl₂N₂O
Molecular Weight:503.348
Hs Code.:

Synonyms:(S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Suppliers and Price of (S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

There total 5 articles about (S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1073556-34-9
(S)-(3,4-dihydroquinolin-1(2H)-yl)(pyrrolidin-2-yl)methanone

: 85482-13-9
2,5-dichlorobenzylbromide

: 76-05-1
trifluoroacetic acid

: 1445981-04-3
(S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Guidance literature:: (S)-(3,4-dihydroquinolin-1(2H)-yl)(pyrrolidin-2-yl)methanone; 2,5-dichlorobenzylbromide; With potassium carbonate; In acetonitrile; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1445981-04-3
(S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: potassium carbonate / acetonitrile / 2 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1371408-36-4
(S)-tert-butyl 2-(1,2,3,4-tetrahydroquinoline-1-carbonyl)pyrrolidine-1-carboxylate

: 1445981-04-3
(S)-(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / acetonitrile / 2 h / 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308