(4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

Base Information

Chemical Name:(4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone
CAS No.:1402612-62-7
Molecular Formula:C₂₇H₂₆N₄O₂
Molecular Weight:438.529
Hs Code.:
European Community (EC) Number:808-589-3
Nikkaji Number:J3.240.315H
ChEMBL ID:CHEMBL3263577

Synonyms:4-(3'-(hydroxymethyl)(1,1'-biphenyl)-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenyl-1-piperidinyl)-methanone;KT182

Suppliers and Price of (4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:438.20557608
Heavy Atom Count:33
Complexity:632

Purity/Quality:: ≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(C(C1)C2=CC=CC=C2)C(=O)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC(=C5)CO

Technology Process of (4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

There total 3 articles about (4-(3'-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1402612-57-0
(4-(4-bromophenyl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1402612-62-7
(4-(3′-(hydroxymethyl)-[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 5301-98-4
4-(4-bromophenyl)-1H-1,2,3-triazole

: 1402612-62-7
(4-(3′-(hydroxymethyl)-[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 4 °C / Inert atmosphere

1.2: 2 h / 60 °C / Inert atmosphere

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 3466-80-6
2-phenylpiperidine

: 1402612-62-7
(4-(3′-(hydroxymethyl)-[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 4 °C / Inert atmosphere

1.2: 2 h / 60 °C / Inert atmosphere

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;