*,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: *,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate
• CAS No.: 101249-96-1
• Molecular Formula: C₂₁H₃₀N₂O₆
• Molecular Weight: 406.479

Synonyms:*,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Chemical Property of *,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of *,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

There total 9 articles about *,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

*,R*)>-phenylmethyl 2-<<<1-<<2-(1,1-dimethylethoxy)-oxoethoxy>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-47-9) → *,R*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101249-96-1)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 0.25h;

DOI:10.1021/jm00156a012

Reference yield:

(S)-2-amino-4-methylpentan-1-ol (7533-40-6,14438-11-0) → *,R*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101249-96-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 64 percent / NaOAc / acetone; H₂O / 2 h / Ambient temperature

2: 24 percent / NaH / tetrahydrofuran / 14 h / Ambient temperature

3: aq. HCl / 4 h / Heating

4: aq. NaOH / 1 h

5: concd. H₂SO₄ / CH₂Cl₂ / 65.5 h

6: H₂ / 20percent Pd/C / methanol / 0.25 h

7: 1H-benzotriazol-1-ol (HOBT), DCC / CH₂Cl₂ / 14 h / Ambient temperature

8: 75.5 percent / trifluoroacetic acid (TFA) / 0.25 h / 0 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; sodium acetate; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; acetone;

DOI:10.1021/jm00156a012

Reference yield:

(S)-2-chloro-N-<1-(hydroxymethyl)-3-methylbutyl>acetamide (101250-43-5) → *,R*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101249-96-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 24 percent / NaH / tetrahydrofuran / 14 h / Ambient temperature

2: aq. HCl / 4 h / Heating

3: aq. NaOH / 1 h

4: concd. H₂SO₄ / CH₂Cl₂ / 65.5 h

5: H₂ / 20percent Pd/C / methanol / 0.25 h

6: 1H-benzotriazol-1-ol (HOBT), DCC / CH₂Cl₂ / 14 h / Ambient temperature

7: 75.5 percent / trifluoroacetic acid (TFA) / 0.25 h / 0 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm00156a012

upstream raw materials:

*,R^*)>-phenylmethyl 2-<<<1-<<2-(1,1-dimethylethoxy)-oxoethoxy>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

(S)-2-amino-4-methylpentan-1-ol

S-5-amino-7-methyl-3-oxaoctanoic acid

(S)-2-chloro-N-<1-(hydroxymethyl)-3-methylbutyl>acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 101249-96-1 *,R^*)>-phenylmethyl 2-<<<1-<(carboxymethoxy)methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send