1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

Base Information

Chemical Name:1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea
CAS No.:549490-80-4
Molecular Formula:C₁₈H₂₀N₄O₃
Molecular Weight:340.382
Hs Code.:

1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6<i>H</i>,10<i>H</i>-dipyrrolo[1,2-<i>a</i>;1',2'-<i>d</i>]pyrazin-5a-yl)-urea

Synonyms:1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

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Chemical Property of 1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

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Technology Process of 1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

There total 8 articles about 1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 549490-78-0
acetic acid 5a-(3-benzyl-ureido)-10-oxo-5a,6,7,8-tetrahydro-5H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5-yl ester

: 549490-80-4
1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

Guidance literature:: With ammonia; In methanol;
DOI:10.1021/ja034575i

Reference yield:

: 549490-72-4
5,10-dioxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazine-5a-carboxylic acid benzyl ester

: 549490-80-4
1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / NaBH₄ / methanol / 0.25 h / -40 °C

2: 66 percent / pyridine / CH₂Cl₂

3: H₂ / 10 percent Pd/C / ethyl acetate

4: TEA; DPPA; 4 Angstroem molecular sieves / toluene / 85 °C

5: toluene / 23 °C

6: 86 percent / NH₃ / methanol

With pyridine; sodium tetrahydroborate; 4 A molecular sieve; TEA; diphenyl-phosphinic acid; ammonia; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/ja034575i

Reference yield:

: 549490-74-6
5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazine-5a-carboxylic acid benzyl ester

: 549490-80-4
1-benzyl-3-(5-hydroxy-10-oxo-7,8-dihydro-6H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazin-5a-yl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / pyridine / CH₂Cl₂

2: H₂ / 10 percent Pd/C / ethyl acetate

3: TEA; DPPA; 4 Angstroem molecular sieves / toluene / 85 °C

4: toluene / 23 °C

5: 86 percent / NH₃ / methanol

With pyridine; 4 A molecular sieve; TEA; diphenyl-phosphinic acid; ammonia; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/ja034575i