8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Base Information

Chemical Name:8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester
CAS No.:1337966-02-5
Molecular Formula:C₂₁H₂₅ClN₄O₃
Molecular Weight:416.908
Hs Code.:

Synonyms:8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Suppliers and Price of 8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

There total 11 articles about 8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1337966-01-4
cis/trans-8-chloro-1-(4-hydroxycyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

: 1337966-02-5
8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: cis/trans-8-chloro-1-(4-hydroxycyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -65 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -65 ℃; for 1.08333h;

Reference yield: 90.0%

: trans-8-chloro-1-(4-hydroxy-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

: 1337966-02-5
8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: trans-8-chloro-1-(4-hydroxy-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -65 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -65 ℃; for 1.08333h;

Reference yield:

: 50608-35-0
(5-chloro-2-nitrobenzylamino)acetic acid ethyl ester

: 1337966-02-5
8-chloro-1-(4-oxo-cyclohexyl)-4H,6H-2,3,5,10b-tetraazabenzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / dichloromethane / 18 h / 0 - 20 °C

2: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 48 h / Inert atmosphere

3: potassium tert-butylate / tetrahydrofuran / 5 - 20 °C / Cooling with ice

4: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

5: butan-1-ol / Reflux

6: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -65 - -50 °C

With Lawessons reagent; dmap; oxalyl dichloride; potassium tert-butylate; hydrogen; dimethyl sulfoxide; triethylamine; zinc dibromide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; butan-1-ol;