3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

Base Information

Chemical Name:3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester
CAS No.:1455089-13-0
Molecular Formula:C₂₂H₂₂N₂O₆
Molecular Weight:410.426
Hs Code.:

Synonyms:3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

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Chemical Property of 3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

Chemical Property:

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Technology Process of 3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

There total 3 articles about 3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1455093-70-5
3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

: 1455089-13-0
3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

Guidance literature:: With lithium hydroxide monohydrate; In methanol; water; at 20 ℃;

Reference yield:

: 808115-59-5
4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carboxylic acid butyl ester

: 1455089-13-0
3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / N,N-dimethyl-formamide; methanol / 1.5 h / 80 °C

2: sodium methylate / methanol / 6 h / 120 °C / Microwave irradiation

3: lithium hydroxide monohydrate / methanol; water / 20 °C

With lithium hydroxide monohydrate; sodium methylate; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1455093-68-1
4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carboxylic acid methyl ester

: 1455089-13-0
3-{[4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 6 h / 120 °C / Microwave irradiation

2: lithium hydroxide monohydrate / methanol; water / 20 °C

With lithium hydroxide monohydrate; sodium methylate; In methanol; water;