2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one

Base Information

• Chemical Name: 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one
• CAS No.: 1448438-03-6
• Molecular Formula: C₂₂H₃₀N₄O₃
• Molecular Weight: 398.505
• Mol file: 1448438-03-6.mol

Synonyms:2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one

Chemical Property of 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one

There total 1 articles about 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(3-chloropropyl)morpholine (7357-67-7) + 2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one (1355994-25-0) → 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one (1448438-03-6)

Guidance literature:

2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one; With 15-crown-5; sodium t-butanolate; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-(3-chloropropyl)morpholine; In tetrahydrofuran; Reflux;

Reference yield: 25.0%

1-(5-fluoropyrimidin-2-yl)thiourea (1322703-83-2) + 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one (1448438-03-6) → N-(5-fluoropyrimidin-2-yl)-8-(4-methoxybenzyl)-6-(3-morpholinopropyl)-4,5,6,8-tetrahydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-2-amine

Guidance literature:

With pyridine; iodine; at 80 ℃; for 1h; Inert atmosphere;

Reference yield: 25.0%

1-(5-fluoropyrimidin-2-yl)thiourea (1322703-83-2) + 2-(4-methoxybenzyl)-8-(3-morpholinopropyl)-5,6,7,8-tetrahydro pyrazolo[3,4-b]azepin-4(2H)-one (1448438-03-6) → N-(5-fluoropyrimidin-2-yl)-8-(4-methoxybenzyl)-6-(3-morpholinopropyl)-4,5,6,8-tetrahydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-2-amine

Guidance literature:

With pyridine; iodine; at 80 ℃; for 1h; Inert atmosphere;

upstream raw materials:

4-(3-chloropropyl)morpholine

2-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one