(+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide

Base Information

• Chemical Name: (+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide
• CAS No.: 101699-34-7
• Molecular Formula: C₂₃H₂₆N₄O₃S
• Molecular Weight: 438.55
• Mol file: 101699-34-7.mol

Synonyms:(+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide

Chemical Property of (+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide

There total 1 articles about (+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2r-(4-phenylcarbamoyl-butyl)-4c-(N'-phenyl-ureido)-tetrahydro-thiophene-3c-carboxylic acid hydrazide → (+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide (101699-34-7)

Guidance literature:

With hydrogenchloride; n-Butyl nitrite; butan-1-ol;

DOI:10.1021/jo01165a023

Reference yield:

(+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide (101699-34-7) → biotin (58-85-5,22879-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1: barium hydroxide; aqueous methanol / 160 °C

2: aqueous K₂CO₃

3: L-arginine

With methanol; barium dihydroxide; L-arginine; potassium carbonate;

DOI:10.1021/jo01165a023

Reference yield:

(+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide (101699-34-7) → (+/-)-biotin (58-85-5,4375-00-2,4443-68-9,5652-41-5,15720-24-8,21788-37-4,22377-59-9,57378-70-8,58073-87-3,68225-55-8,22879-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: barium hydroxide; aqueous methanol / 160 °C

2: aqueous K₂CO₃

With methanol; barium dihydroxide; potassium carbonate;

DOI:10.1021/jo01165a023

Downstream raw materials:

biotin

(+/-)-biotin