1-(M-TOLYL)IMIDAZOLE

Base Information

• Chemical Name: 1-(M-TOLYL)IMIDAZOLE
• CAS No.: 25364-43-6
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Hs Code.: 2933290090
• Mol file: 25364-43-6.mol

Synonyms:Imidazole,1-m-tolyl- (8CI);1-(3-Methylphenyl)-1H-imidazole;

Chemical Property of 1-(M-TOLYL)IMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.00192mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 301.1 °C at 760 mmHg
• PKA: 5.49±0.10(Predicted)
• Flash Point: 135.9 °C
• PSA: 17.82000
• Density: 1.047 g/cm³
• LogP: 2.18070

Purity/Quality:

97% ^*data from raw suppliers

1-(m-tolyl)imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(M-TOLYL)IMIDAZOLE

There total 6 articles about 1-(M-TOLYL)IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1H-imidazole (288-32-4) + m-tolylboronic acid (17933-03-8) → 1-m-tolyl-1H-imidazole (25364-43-6)

Guidance literature:

With [Cu₃₀I₁₆(5-methyl-4-(p-tolyl)pyrimidine-2-thiolato)₁₂(μ₁₀-S₄)]; In methanol; for 5h; Temperature; Reagent/catalyst; Reflux;

DOI:10.1039/c2cc36736j

Reference yield: 98.0%

1H-imidazole (288-32-4) + 3-Iodotoluene (625-95-6) → 1-m-tolyl-1H-imidazole (25364-43-6)

Guidance literature:

With 1,2,3-Benzotriazole; potassium tert-butylate; copper(l) iodide; In dimethyl sulfoxide; at 110 ℃;

DOI:10.1016/j.tetlet.2007.04.061

Reference yield: 88.0%

1H-imidazole (288-32-4) + meta-bromotoluene (591-17-3) → 1-m-tolyl-1H-imidazole (25364-43-6)

Guidance literature:

With potassium phosphate; copper(l) iodide; tetrabutylammomium bromide; 1,10-phenanthroline-4,7-diol; In water; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1002/cctc.201300257

upstream raw materials:

1H-imidazole

m-tolylboronic acid

1-chloro-3-methylbenzene

meta-bromotoluene

Downstream raw materials:

3-phenyl-1-m-tolyl-1H-imidazol-3-ium tetrafluoroborate