[(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester

Base Information

• Chemical Name: [(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester
• CAS No.: 1172048-20-2
• Molecular Formula: C₂₅H₃₀ClN₇O₉
• Molecular Weight: 608.008

Synonyms:[(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester

Chemical Property of [(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester

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Technology Process of [(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester

There total 1 articles about [(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

[(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-hydroxyethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester (1172048-19-9) → [(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester (1172048-20-2)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol9009859

Reference yield: 78.0%

[(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester (1172048-20-2) → [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxytetrahydrofuran-2-ylmethyl](2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester (1172048-22-4)

Guidance literature:

With water; trifluoroacetic acid; at 0 - 20 ℃;

DOI:10.1021/ol9009859

upstream raw materials:

[(3aR,4R,6R,6aR)-6-(6-aminopurin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ylmethyl]-(2-hydroxyethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester

Downstream raw materials:

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxytetrahydrofuran-2-ylmethyl](2-chloroethyl)carbamic acid 4,5-dimethoxy-2-nitrobenzyl ester

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