1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

Base Information

Chemical Name:1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine
CAS No.:179482-31-6
Molecular Formula:C₁₉H₂₃ClF₂N₂O₂
Molecular Weight:384.854
Hs Code.:

Synonyms:1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

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Chemical Property of 1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

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Technology Process of 1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

There total 3 articles about 1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 54512-75-3
1-bromo-5-chloropentane

: 179482-30-5,252327-18-7,252327-19-8
6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

: 179482-31-6
1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

Guidance literature:: 6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine; With sodium hydride; In tetrahydrofuran; for 20h;

1-bromo-5-chloropentane; In tetrahydrofuran; Heating;
DOI:10.1021/jm9902032

Reference yield: 75.0%

: 179482-31-6
1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

Guidance literature:

Reference yield:

: methyl 2-{(3,4-difluorophenyl)methylene}-3-oxobutyrate

: 179482-31-6
1-(5-chloropent-1-yl)-6-(3,4-difluorophenyl)-1,6-dihydro-5-methoxycarbonyl-2,4-dimethylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuOK / dimethylformamide / 0.5 h / 0 °C

1.2: 59 percent / p-TsOH*H₂O / dimethylformamide / 2 h / 100 - 120 °C

2.1: NaH / tetrahydrofuran / 20 h

2.2: 75 percent / tetrahydrofuran / Heating

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Condensation / 1.2: Dehydration / 2.1: Metallation / 2.2: Alkylation;
DOI:10.1021/jm9902032