Technology Process of 6-ethyl 5-amino-2,3-di-O-benzyl-5-deoxy-D-glucarate-1,5-lactam
There total 9 articles about 6-ethyl 5-amino-2,3-di-O-benzyl-5-deoxy-D-glucarate-1,5-lactam which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-ethyl 5-azido-2,3-di-O-benzyl-5-deoxy-D-glucarate-1,4-lactone;
With
hydrogen;
Lindlar's catalyst;
In
ethanol;
for 4h;
under 750.06 Torr;
With
nitrogen;
In
ethanol;
for 12h;
DOI:10.1016/j.tetlet.2005.03.188
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 100 percent / 15 h
2.1: (i-Pr)2NEt / tetrahydrofuran / 2 h / -15 - 0 °C
3.1: NaBH4 / methanol / 3 h / 0 °C
4.1: 35 percent / trichloroisocyanuric acid; TEMPO / tetrahydrofuran / -70 - -10 °C
5.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
5.2: 80 percent / tetrahydrofuran / 1 h
6.1: 75 percent / (DHQ)2PHAL; K3[Fe(CN)6]; K2CO3 / MeSO2NH2; OsO4 / H2O; 2-methyl-propan-2-ol / 6 h / 0 - 5 °C
7.1: 93 percent / CH2Cl2 / 0.08 h / -78 °C
8.1: 98 percent / tetramethylguanidinium azide / CH2Cl2 / 3 h / -90 - 10 °C
9.1: 65 percent / H2 / Pd/CaCO3 / ethanol / 4 h / 750.06 Torr
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium tetrahydroborate; Hydroquinone 1,4-phthalazinediyl diether; trichloroisocyanuric acid; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetramethylguanidinum azide; potassium hexacyanoferrate(III);
Lindlar's catalyst; osmium(VIII) oxide; methanesulfonamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; tert-butyl alcohol;
5.1: Wittig-Horner olefination / 5.2: Wittig-Horner olefination;
DOI:10.1002/hlca.200690066
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
1.2: 80 percent / tetrahydrofuran / 1 h
2.1: 75 percent / (DHQ)2PHAL; K3[Fe(CN)6]; K2CO3 / MeSO2NH2; OsO4 / H2O; 2-methyl-propan-2-ol / 6 h / 0 - 5 °C
3.1: 93 percent / CH2Cl2 / 0.08 h / -78 °C
4.1: 98 percent / tetramethylguanidinium azide / CH2Cl2 / 3 h / -90 - 10 °C
5.1: 65 percent / H2 / Pd/CaCO3 / ethanol / 4 h / 750.06 Torr
With
Hydroquinone 1,4-phthalazinediyl diether; hydrogen; sodium hydride; potassium carbonate; tetramethylguanidinum azide; potassium hexacyanoferrate(III);
Lindlar's catalyst; osmium(VIII) oxide; methanesulfonamide;
In
tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol;
1.1: Wittig-Horner olefination / 1.2: Wittig-Horner olefination;
DOI:10.1002/hlca.200690066
