tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

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Chemical Name:tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate
CAS No.:1352950-73-2
Molecular Formula:C₃₅H₄₃N₃O₄
Molecular Weight:569.744
Hs Code.:

Synonyms:tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

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Chemical Property of tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

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Technology Process of tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

There total 5 articles about tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1352949-95-1
tert-butyl 3-((4-oxo-8-(4-oxo-4-phenylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

: 1352950-73-2
tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 - 41 ℃; for 16.5h;

Reference yield:

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1352950-73-2
tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C

2: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4: potassium carbonate; sodium iodide / butanone / 18 h / 78 °C

5: sodium tetrahydroborate / ethanol / 16.5 h / 20 - 41 °C

With pyridine; sodium tetrahydroborate; hydrogen; sodium hexamethyldisilazane; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; butanone;

Reference yield:

: 1352948-13-0
benzyl 3-(3-(tert-butoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

: 1352950-73-2
tert-butyl 3-((8-(4-hydroxy-4-phenylbutyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

2: potassium carbonate; sodium iodide / butanone / 18 h / 78 °C

3: sodium tetrahydroborate / ethanol / 16.5 h / 20 - 41 °C

With sodium tetrahydroborate; hydrogen; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In methanol; ethanol; butanone;