(E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

Base Information

Chemical Name:(E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid
CAS No.:177469-84-0
Molecular Formula:C₂₆H₂₈N₂O₄
Molecular Weight:432.519
Hs Code.:

Synonyms:(E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

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Chemical Property of (E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

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Technology Process of (E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

There total 10 articles about (E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 177469-83-9
(R)-2-E-[cyclohexyl-4-(2-quinolinylmethoxy)phenyl]methoxyiminopropionic acid methyl ester

: 177469-84-0
(E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; for 10h; Ambient temperature;
DOI:10.1016/0957-4166(96)00340-0

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 177469-84-0
(E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / tetrahydrofuran / 12 h / Ambient temperature

2: 6.6 g / Ph₃P, DEAD / tetrahydrofuran / 16 h / Ambient temperature

3: 96 percent / NH₂NH₂*H₂O / dioxane; ethanol / 0.5 h / Heating

5: 100 mg / AcOH / methanol; dioxane / 12 h / Ambient temperature

6: 76 percent / 1N NaOH / dioxane; methanol / 10 h / Ambient temperature

With sodium hydroxide; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;
DOI:10.1016/0957-4166(96)00340-0

Reference yield:

: 3747-74-8
2-(chloromethyl)quinoline monohydrochloride

: 177469-84-0
(E)-(R)-2-cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyiminopropionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

2: 94 percent / tetrahydrofuran / 12 h / Ambient temperature

3: 6.6 g / Ph₃P, DEAD / tetrahydrofuran / 16 h / Ambient temperature

4: 96 percent / NH₂NH₂*H₂O / dioxane; ethanol / 0.5 h / Heating

6: 100 mg / AcOH / methanol; dioxane / 12 h / Ambient temperature

7: 76 percent / 1N NaOH / dioxane; methanol / 10 h / Ambient temperature

With sodium hydroxide; potassium carbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(96)00340-0