(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1449667-53-1
Molecular Formula:C₂₂H₂₈N₆O
Molecular Weight:392.504
Hs Code.:

Synonyms:(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

There total 8 articles about (3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449667-53-1
(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 4 h / 85 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

5.2: 0 - 20 °C

6.1: sodium hydroxide / tetrahydrofuran; water / 0.33 h / 100 °C / Microwave irradiation

6.2: 24 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; acetic acid; sodium hydroxide; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1449664-55-4
methyl 3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)benzoate

: 1449667-53-1
(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: methyl 3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)benzoate; With sodium hydroxide; In tetrahydrofuran; water; at 100 ℃; for 0.333333h; Microwave irradiation;

1-methyl-piperazine; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 153304-75-7
4-amino-3-ethylbenzoic acid methyl ester

: 1449667-53-1
(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 4 h / 85 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 0.33 h / 100 °C / Microwave irradiation

3.2: 24 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; sodium hydroxide; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;