5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine

Base Information

Chemical Name:5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine
CAS No.:219921-70-7
Molecular Formula:C₁₄H₂₁ClN₂
Molecular Weight:252.787
Hs Code.:
DSSTox Substance ID:DTXSID801179254

Synonyms:DTXSID801179254;5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine;219921-70-7

Suppliers and Price of 5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:252.1393264
Heavy Atom Count:17
Complexity:246

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CCCN(C1)C2=C(C=C(C=C2)Cl)C(C)N

Technology Process of 5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine

There total 6 articles about 5-Chloro-alpha-methyl-2-(3-methyl-1-piperidinyl)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16588-02-6
4-chloro-3-cyanonitrobenzene

: 219921-70-7
1-(5-chloro-2-(3-methyl-piperidino)-phenyl)-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Heating

2: Fe, aq. NH₄Cl / 2 h / Heating

3: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) 0 deg C, 2.) 40 deg C, 2 h

4: diethyl ether / 94 h / Heating

5: LiAlH₄ / diethyl ether / 4 h / Heating

With copper(I) chloride; hydrogenchloride; lithium aluminium tetrahydride; iron; ammonium chloride; sodium nitrite; In diethyl ether; ethanol;
DOI:10.1021/jm9810349

Reference yield:

: 626-56-2,53152-98-0
3-Methylpiperidine

: 219921-70-7
1-(5-chloro-2-(3-methyl-piperidino)-phenyl)-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Heating

2: Fe, aq. NH₄Cl / 2 h / Heating

3: 1.) aq. NaNO₂, HCl, 2.) Cu₂Cl₂, HCl / 1.) 0 deg C, 2.) 40 deg C, 2 h

4: diethyl ether / 94 h / Heating

5: LiAlH₄ / diethyl ether / 4 h / Heating

With copper(I) chloride; hydrogenchloride; lithium aluminium tetrahydride; iron; ammonium chloride; sodium nitrite; In diethyl ether; ethanol;
DOI:10.1021/jm9810349

Reference yield:

: 5-chloro-2-(3-methyl-piperidin-1-yl)-benzonitrile

: 219921-70-7
1-(5-chloro-2-(3-methyl-piperidino)-phenyl)-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 94 h / Heating

2: LiAlH₄ / diethyl ether / 4 h / Heating

With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1021/jm9810349