4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Base Information

Chemical Name:4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl
CAS No.:912818-51-0
Molecular Formula:C₃₉H₃₈O₆
Molecular Weight:602.727
Hs Code.:

Synonyms:4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Suppliers and Price of 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

There total 9 articles about 4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 912818-45-2
1,2-dideoxy-1β-[4-(4-methoxyphenyl)phenyl]-D-ribofuranose

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 912818-51-0
4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2006.05.072

Reference yield:

: 898828-50-7
4-(2'-deoxy-β-D-ribofuranosyl)-1-bromobenzene

: 912818-51-0
4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 4-(dimethylamino)pyridine; pyridine / 16 h / 20 °C

2: 95 percent / KF; 2-(di-tert-butylphosphino)biphenyl / Pd(OAc)2 / tetrahydrofuran / 16 h / 20 °C

3: 94 percent / K₂CO₃ / methanol / 20 °C

4: 90 percent / pyridine / 4 h / 20 °C

With pyridine; dmap; potassium fluoride; potassium carbonate; johnphos; palladium diacetate; In tetrahydrofuran; methanol; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.05.072

Reference yield:

: 912818-31-6
4-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)-1-bromobenzene

: 912818-51-0
4'-[2''-deoxy-5''-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl]-4-methoxybiphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / KF; 2-(di-tert-butylphosphino)biphenyl / Pd(OAc)2 / tetrahydrofuran / 16 h / 20 °C

2: 94 percent / K₂CO₃ / methanol / 20 °C

3: 90 percent / pyridine / 4 h / 20 °C

With pyridine; potassium fluoride; potassium carbonate; johnphos; palladium diacetate; In tetrahydrofuran; methanol; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.05.072