(S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester
• CAS No.: 77303-01-6
• Molecular Formula: C₄₈H₆₃N₅O₁₂
• Molecular Weight: 902.055

Synonyms:(S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester

Chemical Property of (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester

There total 8 articles about (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionylamino)-4-benzyloxycarbonyl-butyrylamino]-4-benzyloxycarbonyl-butyrylamino}-4-methyl-pentanoic acid methyl ester; hydrochloride → (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester (77303-01-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1021/jm00138a013

Reference yield:

Boc-Glu(OBzl)-OH (13574-13-5) → (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester (77303-01-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 92.2 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

2: 4 N HCl / dioxane / 1 h / Ambient temperature

3: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

4: 4 N HCl / dioxane / 1 h / Ambient temperature

5: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

6: 4 N HCl / dioxane / 1 h / Ambient temperature

7: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm00138a013

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester (77303-01-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 92.2 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

2: 4 N HCl / dioxane / 1 h / Ambient temperature

3: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

4: 4 N HCl / dioxane / 1 h / Ambient temperature

5: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

6: 4 N HCl / dioxane / 1 h / Ambient temperature

7: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 22 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm00138a013

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Glu(OBzl)-OH

methyl (L)-leucinate hydrochloride

benzyl (S)-4-((tert-butoxycarbonyl)amino)-5-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-5-oxopentanoate

Downstream raw materials:

Boc-Phe-Ala-Glu-Glu-Leu-OMe

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