(4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Base Information

Chemical Name:(4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate
CAS No.:1438392-94-9
Molecular Formula:C₂₅H₂₃ClN₂O₃S
Molecular Weight:466.988
Hs Code.:

Synonyms:(4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Suppliers and Price of (4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

There total 6 articles about (4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1438392-80-3
1-(2,5-dimethylbenzyl)-1H-indol-3-yl acetate

: 1438392-70-1
2,2-dichloro-1-(thiophen-2-yl)ethanone oxime

: 1438392-94-9
(4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Guidance literature:: With (S)-(+)-5,5’-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4’-bi-1,3-benzodioxole; silver (II) carbonate; 2CF₃O₃S^(1-)*Cu⁽²⁺⁾*0.5C₇H₈; In dichloromethane; at -78 - 23 ℃; for 64h; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1002/chem.201203435

Reference yield:

: 120-72-9
indole

: 1438392-94-9
(4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 23 °C / Inert atmosphere

1.2: 12 h / 0 - 23 °C / Inert atmosphere

2.1: palladium diacetate; potassium hydroxide / acetonitrile / 12 h / 70 °C / Inert atmosphere

3.1: 2CF3O3S(1-)*Cu(2+)*0.5C7H8; silver (II) carbonate; (S)-(+)-5,5’-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4’-bi-1,3-benzodioxole / dichloromethane / 64 h / -78 - 23 °C / Inert atmosphere; Molecular sieve

With (S)-(+)-5,5’-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4’-bi-1,3-benzodioxole; silver (II) carbonate; 2CF₃O₃S^(1-)*Cu⁽²⁺⁾*0.5C₇H₈; palladium diacetate; sodium hydride; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1002/chem.201203435

Reference yield:

: 35304-56-4
2,2‐dichloro‐1‐(thiophen‐2‐yl)ethan‐1‐one

: 1438392-94-9
(4S,4aS,9aR)-4-chloro-9-(2,5-dimethylbenzyl)-3-(thiophen-2-yl)-4,4a,9,9atetrahydro-[1,2]oxazino[6,5-b]indol-4a-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / ethanol / 12 h / 0 - 23 °C / Inert atmosphere

2: 2CF3O3S(1-)*Cu(2+)*0.5C7H8; silver (II) carbonate; (S)-(+)-5,5’-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4’-bi-1,3-benzodioxole / dichloromethane / 64 h / -78 - 23 °C / Inert atmosphere; Molecular sieve

With (S)-(+)-5,5’-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4’-bi-1,3-benzodioxole; silver (II) carbonate; 2CF₃O₃S^(1-)*Cu⁽²⁺⁾*0.5C₇H₈; hydroxylamine hydrochloride; In ethanol; dichloromethane;
DOI:10.1002/chem.201203435