(E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester

Base Information

• Chemical Name: (E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester
• CAS No.: 1037600-81-9
• Molecular Formula: C₂₇H₂₅NO₄S
• Molecular Weight: 459.566
• Mol file: 1037600-81-9.mol

Synonyms:(E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester

Chemical Property of (E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester

There total 1 articles about (E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-dibenzothiophene boronic acid (108847-20-7) + Boc-(E)-ΔPhe(β-Br)-OMe (606937-27-3) → (E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester (1037600-81-9)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 70 - 80 ℃; for 1.5h;

DOI:10.1016/j.bmc.2008.04.004

Reference yield: 41.0%

(E)-N-(tert-butoxycarbonyl)-β-(dibenzothien-4-yl)dehydrophenylalanine methyl ester (1037600-81-9) → C22H15NO2S (1037600-84-2) + C22H15NO2S (1037600-83-1)

Guidance literature:

With copper diacetate; palladium diacetate; In N,N-dimethyl-formamide; at 130 - 160 ℃; for 7h;

DOI:10.1016/j.bmc.2008.04.004

upstream raw materials:

4-dibenzothiophene boronic acid

Boc-(E)-ΔPhe(β-Br)-OMe

Downstream raw materials:

C₂₂H₁₅NO₂S

C₂₂H₁₅NO₂S

Refernces