(8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Base Information

• Chemical Name: (8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
• CAS No.: 220064-08-4
• Molecular Formula: C₃₅H₄₁N₃O₂
• Molecular Weight: 535.729
• Mol file: 220064-08-4.mol

Synonyms:(8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Chemical Property of (8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

There total 1 articles about (8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-benzyloxyestra-1,3,5(10)-trien-17-one (858-98-0) + 1-(4-bromophenyl)-2-(pyrrolidin-1-yl)diazene (147227-33-6) → (8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (220064-08-4)

Guidance literature:

With boron trifluoride diethyl etherate; sec.-butyllithium; In tetrahydrofuran; at -85 ℃; for 2h;

DOI:10.1016/S0040-4039(98)02185-6

Reference yield: 67.0%

(8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (220064-08-4) → 17α-(4-aminophenyl)estradiol

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 21h; under 750.06 Torr;

DOI:10.1016/S0040-4039(00)01238-7

Reference yield:

(8R,9S,13S,14S,17R)-3-Benzyloxy-13-methyl-17-[4-(pyrrolidin-1-ylazo)-phenyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol (220064-08-4) → (8R,9S,13S,14S,17R)-17-(4-Amino-phenyl)-3-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Guidance literature:

With hydrogen; dichloro bis(acetonitrile) palladium(II); In ethanol; ethyl acetate;

DOI:10.1016/S0040-4039(00)01238-7

upstream raw materials:

3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

1-(4-bromophenyl)-2-(pyrrolidin-1-yl)diazene