1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Base Information

• Chemical Name: 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one
• CAS No.: 1104448-54-5
• Molecular Formula: C₂₄H₂₇FN₄O₄S
• Molecular Weight: 486.567

Synonyms:1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Chemical Property of 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

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Technology Process of 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

There total 7 articles about 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-hydroxypyridin-2(1H)-one (1104448-50-1) + 1-(5-propylpyrimidin-2-yl)piperidin-4-yl methanesulfonate (1101873-46-4) → 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one (1104448-54-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3.75h; Inert atmosphere;

DOI:10.1021/jm501175v

Reference yield:

2-chloro-5-propylpyrimidine (219555-98-3) → 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one (1104448-54-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 2 h / 100 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 3.75 h / 90 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm501175v

Reference yield:

1-(5-propylpyrimidin-2-yl)piperidin-4-ol (1101873-45-3) → 1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one (1104448-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 3.75 h / 90 °C / Inert atmosphere

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm501175v

upstream raw materials:

2-chloro-5-propylpyrimidine

4-HYDROXYPIPERIDINE

1-(5-propylpyrimidin-2-yl)piperidin-4-ol

1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-hydroxypyridin-2(1H)-one

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