2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

Base Information

Chemical Name:2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide
CAS No.:1198620-74-4
Molecular Formula:C₂₀H₂₀FN₃O₅
Molecular Weight:401.394
Hs Code.:

Synonyms:2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

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Chemical Property of 2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

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Technology Process of 2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

There total 4 articles about 2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1198621-44-1
C₂₁H₂₁FN₂O₅

: 1198620-74-4
2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

Guidance literature:: With hydroxylamine hydrochloride; In tetrahydrofuran; water; for 3h; Reflux;

Reference yield:

: 1198621-67-8
5-formyl-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylic acid methyl ester

: 1198620-74-4
2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium chlorite / water; tert-butyl alcohol

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: hydroxylamine hydrochloride / tetrahydrofuran; water / 3 h / Reflux

With sodium chlorite; hydroxylamine hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1198621-19-0
5-carboxyl-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylic acid methyl ester

: 1198620-74-4
2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: hydroxylamine hydrochloride / tetrahydrofuran; water / 3 h / Reflux

With hydroxylamine hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;