3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1613709-06-0
Molecular Formula:C₁₈H₁₄N₂OS
Molecular Weight:306.388
Hs Code.:

Synonyms:3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

There total 5 articles about 3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1613709-06-0
3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; N-chloro-succinimide / 4 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 °C / Inert atmosphere

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 4.25 h / 85 °C / Inert atmosphere; Sealed tube

4: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 85 °C / Inert atmosphere; Sealed tube

5: potassium carbonate; water / methanol / 12 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydride; potassium carbonate; caesium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1613711-73-1
C₂₅H₂₀N₂O₃S₂

: 1613709-06-0
3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With water; potassium carbonate; In methanol; at 60 ℃; for 12h;

Reference yield:

: 869335-73-9
4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine

: 1613709-06-0
3-(2-methoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 °C / Inert atmosphere

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 4.25 h / 85 °C / Inert atmosphere; Sealed tube

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 85 °C / Inert atmosphere; Sealed tube

4: potassium carbonate; water / methanol / 12 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydride; potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;