(+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

Base Information

Chemical Name:(+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide
CAS No.:869468-29-1
Molecular Formula:C₂₄H₃₂N₂O₄
Molecular Weight:412.529
Hs Code.:

Synonyms:(+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

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Chemical Property of (+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

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Technology Process of (+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

There total 4 articles about (+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869468-00-8
E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-hex-2-enamide

: 869468-29-1
(+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi; TMEDA / toluene / 7.5 h / -90 °C

2: H₂ / Pd/C / ethanol / 18 h / 3361.46 Torr

3: 0.27 g / NaOH / dioxane; H₂O / 18 h / 20 °C

With sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jo051207j

Reference yield:

: 97943-16-3
(E)-2-hexenoyl chloride

: 869468-29-1
(+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / Et₃N / tetrahydrofuran / 1.5 h / -20 °C

2: n-BuLi; TMEDA / toluene / 7.5 h / -90 °C

3: H₂ / Pd/C / ethanol / 18 h / 3361.46 Torr

4: 0.27 g / NaOH / dioxane; H₂O / 18 h / 20 °C

With sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jo051207j

Reference yield:

: 869468-01-9
(+)-(1'S,2'S,3R)-3-dibenzylamino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

: 869468-29-1
(+)-(1'S,2'S,3R)-3-(benzyloxycarbonyl)amino-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 18 h / 3361.46 Torr

2: 0.27 g / NaOH / dioxane; H₂O / 18 h / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jo051207j