5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid
CAS No.:1374344-54-3
Molecular Formula:C₁₇H₂₁N₃O₅
Molecular Weight:347.371
Hs Code.:

Synonyms:5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

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Chemical Property of 5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

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Technology Process of 5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

There total 6 articles about 5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1361235-72-4
methyl 5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

: 1374344-54-3
5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: methyl 5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate; With sodium hydroxide; In methanol; at 20 - 80 ℃; for 2.91h; Inert atmosphere;

With hydrogenchloride; In methanol; water; Inert atmosphere;
DOI:10.1021/jm201331s

Reference yield:

: 1374344-40-7
methyl 5-(azidomethyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

: 1374344-54-3
5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: sodium hydroxide / methanol / 2.91 h / 20 - 80 °C / Inert atmosphere

3.2: Inert atmosphere

With triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm201331s

Reference yield:

: 913375-92-5
methyl 5-(bromomethyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate

: 1374344-54-3
5-((tert-butoxycarbonyl)methyl)-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 0.83 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran; water / 20 °C / Inert atmosphere

3.1: dichloromethane / 1 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: sodium hydroxide / methanol / 2.91 h / 20 - 80 °C / Inert atmosphere

4.2: Inert atmosphere

With sodium azide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201331s