4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

Base Information

Chemical Name:4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile
CAS No.:936133-18-5
Molecular Formula:C₂₄H₃₀N₂O₂
Molecular Weight:378.514
Hs Code.:

Synonyms:4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

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Chemical Property of 4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

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Technology Process of 4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

There total 3 articles about 4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 936133-13-0
4-[[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

: 7051-34-5
cyclopropylcarbinyl bromide

: 936133-18-5
4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2007.02.053

Reference yield:

: 24596-19-8
4-bromo-2,6-dimethylphenylamine

: 936133-18-5
4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / CuI; KI; N,N'-dimethylethylenediamine / dimethylformamide / 24 h / 100 °C

2: 76 percent / 2-(di-cyclohexylphosphino)biphenyl; t-BuONa / Pd₂(dba)3 / toluene / 19 h / 100 °C

3: 61 percent / NaH / dimethylformamide / 0 - 20 °C

With copper(l) iodide; sodium hydride; potassium iodide; sodium t-butanolate; N,N`-dimethylethylenediamine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2007.02.053

Reference yield:

: 74896-24-5
4-amino-3,5-dimethylbenzonitrile

: 936133-18-5
4-[N-(cyclopropylmethyl)-N-[3-isopropyl-4-(methoxymethoxy)phenyl]amino]-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 2-(di-cyclohexylphosphino)biphenyl; t-BuONa / Pd₂(dba)3 / toluene / 19 h / 100 °C

2: 61 percent / NaH / dimethylformamide / 0 - 20 °C

With sodium hydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2007.02.053