5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

Base Information

Chemical Name:5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid
CAS No.:111823-24-6
Molecular Formula:C₂₉H₄₀N₈O₉
Molecular Weight:644.685
Hs Code.:

Synonyms:5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

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Chemical Property of 5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

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Technology Process of 5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

There total 3 articles about 5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 135-16-0
tetrahydrofolic acid

: 78241-56-2
ethyl 6-isocyanatoheptanoate

: 111823-24-6
5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

Guidance literature:: With sodium acetate; In water; for 4h;
DOI:10.1021/jm00398a034

Reference yield:

: 29840-65-1
7-aminoheptanoic acid ethyl ester hydrochloride

: 111823-24-6
5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / toluene / 0.5 h / Heating

2: 21 percent / NaOAc*3H₂O / H₂O / 4 h

With sodium acetate; In water; toluene;
DOI:10.1021/jm00398a034

Reference yield:

: 929-17-9
7-aminoheptanoic acid

: 111823-24-6
5-<<<6-(ethoxycarbonyl)hexyl>amino>carbonyl>-5,6,7,8-tetrahydrofolic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / SOCl₂ / 20 h / Ambient temperature

2: 38 percent / toluene / 0.5 h / Heating

3: 21 percent / NaOAc*3H₂O / H₂O / 4 h

With thionyl chloride; sodium acetate; In water; toluene;
DOI:10.1021/jm00398a034