BOC-ALA-ALA-PNA

Base Information

• Chemical Name: BOC-ALA-ALA-PNA
• CAS No.: 50439-35-5
• Molecular Formula: C17H24 N4 O6
• Molecular Weight: 380.4
• Mol file: 50439-35-5.mol

Synonyms:N-BOC-L-ALA-ALA-P-NITROANILIDE;BOC-L-ALANYL-ALANINE P-NITROANILIDE;BOC-ALA-ALA-PNA;BOC-ALA-ALA-P-NITROANILIDE;N-T-BOC-ALA-ALA P-NITROANILIDE);N-(tert-butoxycarbonylmethyl)alanine-alanine-nitroanilide

Chemical Property of BOC-ALA-ALA-PNA

Chemical Property:

• Boiling Point: 654.8±50.0 °C(Predicted)
• PKA: 11.34±0.46(Predicted)
• PSA: 142.35000
• Density: 1.259±0.06 g/cm3(Predicted)
• LogP: 3.32920
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Boc-Ala-Ala-pNA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-ALA-ALA-PNA

There total 20 articles about BOC-ALA-ALA-PNA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

L-alanine-p-nitroanilide (1668-13-9,26017-82-3,26432-41-7,77286-89-6) + (S)-2-tert-Butoxycarbonylamino-propionic acid 4-guanidinomethyl-phenyl ester; compound with toluene-4-sulfonic acid → Nα-Boc-L-Ala-L-Ala-p-nitroanilide (50439-35-5)

Guidance literature:

With MOPS buffer; calcium chloride; bovine trypsin; In dimethyl sulfoxide; at 25 ℃; for 5h;

DOI:10.1248/cpb.46.846

Reference yield: 88.0%

L-alanine-p-nitroanilide (1668-13-9,26017-82-3,26432-41-7,77286-89-6) + 2-tert-butoxycarbonylamino-propionic acid 6-guanidino-naphthalen-1-yl ester; compound with toluene-4-sulfonic acid → Nα-Boc-L-Ala-L-Ala-p-nitroanilide (50439-35-5)

Guidance literature:

With 3-(N-morpholino)propanesulfonate; calcium chloride; In dimethyl sulfoxide; at 25 ℃; for 12h; trypsin;

DOI:10.1248/cpb.47.104

Reference yield: 83.0%

L-alanine-p-nitroanilide (1668-13-9,26017-82-3,26432-41-7,77286-89-6) + Nα-Boc-L-Ala-OAm*TsOH → Nα-Boc-L-Ala-L-Ala-p-nitroanilide (50439-35-5)

Guidance literature:

With Atlantic cod trypsin [EC 3.4.21.4] (lyophilized); In dimethyl sulfoxide; at 0 ℃; for 0.25h; pH=8.5; aq. buffer; Enzymatic reaction;

DOI:10.1248/cpb.58.484

upstream raw materials:

L-N-Boc-Ala

L-alanine-p-nitroanilide

tert-butyloxycarbonylalanine 4-guanidinophenyl ester

Downstream raw materials:

Boc-Val-ψ-(CH2-NH)-Ala-Ala-pNA