ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

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Chemical Name:ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate
CAS No.:1166311-53-0
Molecular Formula:C₂₉H₃₅N₃O₄
Molecular Weight:489.615
Hs Code.:

Synonyms:ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

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Chemical Property of ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

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Technology Process of ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

There total 1 articles about ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.7%

: 1166311-14-3
1-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]tetrahydropyrimidin-2(1H)-one

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 1166311-53-0
ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

Guidance literature:: 1-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]tetrahydropyrimidin-2(1H)-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; Reflux;

Ethyl 2-bromopropionate; In tetrahydrofuran; Reflux;
DOI:10.1016/j.bmc.2009.04.003

Reference yield: 57.5%

: 1166311-53-0
ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

: 1166312-31-7
N-hydroxy-2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)-phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionamide

Guidance literature:: ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate; With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; water; at 0 ℃; pH=Ca. 6;
DOI:10.1016/j.bmc.2009.04.003

Reference yield: 54.2%

: 1166311-53-0
ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate

: 1166311-92-7
2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionic acid

Guidance literature:: ethyl 2-{3-[4-(2-isobutyl-4-quinolinylmethoxy)phenyl]-2(1H)-oxotetrahydro-1-pyrimidinyl}propionate; With water; In methanol; at 20 ℃; for 2h; Alkaline aq. solution;

With hydrogenchloride; In water;
DOI:10.1016/j.bmc.2009.04.003