(S)-Di-Tert-Butyl 2-(3-((S)-6-Amino-1-(Tert-Butoxy)-1-Oxohexan-2-Yl)Ureido)Pentanedioate

Base Information

• Chemical Name: (S)-Di-Tert-Butyl 2-(3-((S)-6-Amino-1-(Tert-Butoxy)-1-Oxohexan-2-Yl)Ureido)Pentanedioate
• CAS No.: 1025796-31-9
• Molecular Formula: C₂₄H₄₅N₃O₇
• Molecular Weight: 487.637
• Mol file: 1025796-31-9.mol

Synonyms:(S)-2-[3-((S)-5-amino-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester

Chemical Property of (S)-Di-Tert-Butyl 2-(3-((S)-6-Amino-1-(Tert-Butoxy)-1-Oxohexan-2-Yl)Ureido)Pentanedioate

Chemical Property:

• Boiling Point: 596.6±50.0 °C(Predicted)
• PKA: 12.09±0.46(Predicted)
• Density: 1.072±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(S)-Di-tert-butyl2-(3-((S)-6-Amino-1-(tert-butoxy)-1-oxohexan-2-yl)ureido)pentanedioate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (S)-Di-tert-butyl 2-(3-((S)-6-Amino-1-(tert-butoxy)-1-oxohexan-2-yl)ureido)pentanedioate is used as a reactant in the synthesis of novel multivalent fluorescent inhibitors with high affinity to prostate cancer.

Technology Process of (S)-Di-Tert-Butyl 2-(3-((S)-6-Amino-1-(Tert-Butoxy)-1-Oxohexan-2-Yl)Ureido)Pentanedioate

There total 20 articles about (S)-Di-Tert-Butyl 2-(3-((S)-6-Amino-1-(Tert-Butoxy)-1-Oxohexan-2-Yl)Ureido)Pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-[3-((S)-(5-benzyloxycarbonylamino)-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester (1025796-30-8) → (S)-2-[3-((S)-5-amino-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester (1025796-31-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h;

Reference yield: 98.0%

L-(S,S)-2-[3-(5-benzyloxycarbonylamino)-1-tert-butoxycarbonyl-pentyl-ureido]-pentanedioic acid di-tert-butyl ester → (S)-2-[3-((S)-5-amino-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester (1025796-31-9)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In ethanol;

Reference yield: 90.0%

(10S,14S)-tri-tert-butyl 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate → (S)-2-[3-((S)-5-amino-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester (1025796-31-9)

Guidance literature:

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; for 0.5h;

upstream raw materials:

(S)-2-[3-((S)-(5-benzyloxycarbonylamino)-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester

L-glutamic acid di-tert-butyl ester hydrochloride

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester

di-tert-butyl <<(4-nitrophenyl)oxy>carbonyl>-L-glutamate

Downstream raw materials:

(S)-di-tert-butyl 2-(3-((S)-1-tert-butoxy-1-oxo-6-(4-(trimethylstannyl)benzylamino)hexan-2-yl)ureido)pentanedioate

(S)-di-tert-butyl 2-(3-((S)-1-tert-butoxy-6-(3-(4-iodophenyl)ureido)-1-oxohexan-2-yl)ureido)pentanedioate

(S)-2-(3-((S)-1-carboxy-5-(4-(25-(2,4-dinitrophenylamino)-2,5,8,11,14,17,20,23-octaoxapentacosyl)-1H-1,2,3-triazol-1-yl)pentyl)ureido)pentanedioic acid

C₃₁H₄₈N₄O₁₁