Technology Process of 22-Oxo-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diyl diacetate
There total 11 articles about 22-Oxo-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diyl diacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at -65 ℃;
for 4.5h;
DOI:10.1246/bcsj.62.3132
- Guidance literature:
-
Multi-step reaction with 8 steps
1: t-BuOK / tetrahydrofuran / 33 h / Ambient temperature
2: 4-(dimethylamino)pyridine, pyridine / 0.75 h / Ambient temperature
3: 80 percent / boron trifluoride etherate / CH2Cl2 / 1 h / Ambient temperature
4: 98 percent / H2 / 5percent Pt/C / ethanol / Ambient temperature
5: N-bromosuccinimide / CCl4 / 0.25 h / Heating
6: 1.) n-Bu4NBr, 2.) n-Bu4NF / 1.) THF, r.t., 1 h, 2.) hexane, r.t., 45 min
7: ethyl acetate
8: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) to r.t., 50 min
With
pyridine; dmap; N-Bromosuccinimide; oxalyl dichloride; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; dimethyl sulfoxide; triethylamine;
platinum on activated charcoal;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00027a010
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 4-(dimethylamino)pyridine, pyridine / 0.75 h / Ambient temperature
2: 80 percent / boron trifluoride etherate / CH2Cl2 / 1 h / Ambient temperature
3: 98 percent / H2 / 5percent Pt/C / ethanol / Ambient temperature
4: N-bromosuccinimide / CCl4 / 0.25 h / Heating
5: 1.) n-Bu4NBr, 2.) n-Bu4NF / 1.) THF, r.t., 1 h, 2.) hexane, r.t., 45 min
6: ethyl acetate
7: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 15 min, 2.) to r.t., 50 min
With
pyridine; dmap; N-Bromosuccinimide; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; dimethyl sulfoxide; triethylamine;
platinum on activated charcoal;
In
tetrachloromethane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00027a010
