N²-[3-(Benzyl-methyl-amino)-propyl]-N²-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine

Base Information

• Chemical Name: N²-[3-(Benzyl-methyl-amino)-propyl]-N²-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine
• CAS No.: 98902-22-8
• Molecular Formula: C₂₃H₃₁N₅O₂
• Molecular Weight: 409.531

Synonyms:N²-[3-(Benzyl-methyl-amino)-propyl]-N²-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine

Chemical Property of N²-[3-(Benzyl-methyl-amino)-propyl]-N²-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine

Chemical Property:

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Technology Process of N²-[3-(Benzyl-methyl-amino)-propyl]-N²-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine

There total 1 articles about N²-[3-(Benzyl-methyl-amino)-propyl]-N²-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-Benzyl-N'-ethyl-N-methyl-propane-1,3-diamine (98902-20-6) + 2-chloro-6,7-dimethoxyquinazolin-4-amine (23680-84-4) → N2-[3-(Benzyl-methyl-amino)-propyl]-N2-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine (98902-22-8)

Guidance literature:

In pyridine; at 130 ℃; for 0.5h;

DOI:10.1021/jm00151a003

Reference yield:

N2-[3-(Benzyl-methyl-amino)-propyl]-N2-ethyl-6,7-dimethoxy-quinazoline-2,4-diamine (98902-22-8) → N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-ethyl-amino]-propyl}-N-methyl-benzamide (98902-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / H₂, HCl / 5percent Pd/C / ethanol; methanol / 80 °C / 14480.1 Torr

2: NaOH / H₂O; CHCl₃ / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol; chloroform; water;

DOI:10.1021/jm00151a003

upstream raw materials:

N-Benzyl-N'-ethyl-N-methyl-propane-1,3-diamine

2-chloro-6,7-dimethoxyquinazolin-4-amine

Downstream raw materials:

N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-ethyl-amino]-propyl}-N-methyl-benzamide

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