2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester
• CAS No.: 461385-09-1
• Molecular Formula: C₃₃H₃₂N₂O₃
• Molecular Weight: 504.629

Synonyms:2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

Chemical Property of 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

There total 4 articles about 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzylamine (100-46-9) + 2R,5R,6S-2-(2-oxoethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester (461385-08-0) → 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester (461385-09-1)

Guidance literature:

With aluminum oxide; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jo025636i

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester (461385-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / (C₂H₅)3N; 4-dimethylaminopyridine / CCl₃F / 5.5 h / 20 °C

2: 85 percent / di-(isobutyl)aluminum hydride / CH₂Cl₂; toluene / 2 h / -78 °C

3: 98 percent / Al₂O₃ / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; aluminum oxide; diisobutylaluminum hydride; triethylamine; In dichloromethane; trichlorofluoromethane; toluene;

DOI:10.1021/jo025636i

Reference yield:

2R,5R,6S-2-(methoxycarbonylmethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester (461385-07-9) → 2R,5R,6S-2-(2-(benzylimino)ethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester (461385-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / di-(isobutyl)aluminum hydride / CH₂Cl₂; toluene / 2 h / -78 °C

2: 98 percent / Al₂O₃ / CH₂Cl₂ / 0.5 h / 0 °C

With aluminum oxide; diisobutylaluminum hydride; In dichloromethane; toluene;

DOI:10.1021/jo025636i

upstream raw materials:

benzylamine

2R,5R,6S-2-(2-oxoethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

benzyl chloroformate

2R,5R,6S-2-(methoxycarbonylmethyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

Downstream raw materials:

2R,2'R,5R,6S-2-(2'-((benzyl)(benzyloxycarbonyl)amino)-4'-oxobutyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

2R,2'R,5R,6S-2-(2'-((benzyl)(benzyloxycarbonyl)amino)-3'-carboxypropyl)-5,6-diphenylmorpholine-4-carboxylic acid benzyl ester

(2S,3R,6R)-6-[(R)-2-(Benzyl-benzyloxycarbonyl-amino)-3-(N'-benzyloxycarbonylmethyl-N'-methyl-hydrazinocarbonyl)-propyl]-2,3-diphenyl-morpholine-4-carboxylic acid benzyl ester

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