Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

Base Information

Chemical Name:Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester
CAS No.:120051-13-0
Molecular Formula:C₆₂H₆₁F₂O₁₄P₃
Molecular Weight:1161.08
Hs Code.:

Synonyms:Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

There total 4 articles about Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 120051-12-9
(1S,2S,4R,5R,6R)-5,6-Bis-benzyloxy-3,3-difluoro-cyclohexane-1,2,4-triol

: 120051-13-0
Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/S0040-4039(00)80720-0

Reference yield:

: 111392-18-8,140148-51-2
(+/-)-1,3,4-tri-O-allyl-5,6-di-O-benzyl-myo-inositol

: 120051-13-0
Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / DMSO/Ac₂O

2: 60 percent / DAST / CHCl₃ / 24 h / Ambient temperature

3: 90 percent / pTSA / 10 percent Pd/C / ethanol; H₂O / Heating

4: 66 percent / NaH / dimethylformamide / 0 °C

With acetic anhydride; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)80720-0

Reference yield:

: 120051-10-7
(2S,3R,4R,5S,6R)-2,3,6-Tris-allyloxy-4,5-bis-benzyloxy-cyclohexanone

: 120051-13-0
Phosphoric acid dibenzyl ester (1S,2R,4S,5R,6R)-5,6-bis-benzyloxy-2,4-bis-(bis-benzyloxy-phosphoryloxy)-3,3-difluoro-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / DAST / CHCl₃ / 24 h / Ambient temperature

2: 90 percent / pTSA / 10 percent Pd/C / ethanol; H₂O / Heating

3: 66 percent / NaH / dimethylformamide / 0 °C

With sodium hydride; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)80720-0