(R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone

Base Information

• Chemical Name: (R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone
• CAS No.: 1215840-52-0
• Molecular Formula: C₂₂H₂₆OSi
• Molecular Weight: 334.533
• Mol file: 1215840-52-0.mol

Synonyms:(R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone

Chemical Property of (R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone

Chemical Property:

Purity/Quality:

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Technology Process of (R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone

There total 2 articles about (R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C14H14O (100885-83-4) + dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane (185990-03-8) → (R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone (1215840-52-0)

Guidance literature:

With [Ph₂C₃H₃N₂(C₆H₄Ph)2]BF₄; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; at -78 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja910989n

Reference yield:

C14H14O (100885-83-4) + dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane (185990-03-8) → (R,Z)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethylidene)cyclohexanone (1215840-52-0) + (R)-3-(2-(dimethyl(phenyl)silyl)-2-phenylethyl)cyclohex-2-en-1-one

Guidance literature:

With C₂₀H₂₈N₂O₂*Cu⁽²⁺⁾*2C₅H₇O₂^(1-); In water; at 20 ℃; for 3h; enantioselective reaction;

DOI:10.1021/jacs.5b11418

upstream raw materials:

C₁₄H₁₄O

dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane