BOC-PHE-LEU-OH

Base Information

• Chemical Name: BOC-PHE-LEU-OH
• CAS No.: 33014-68-5
• Molecular Formula: C20H30 N2 O5
• Molecular Weight: 378.469
• Mol file: 33014-68-5.mol

Synonyms:L-Leucine,N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-; a-tert-Butoxycarbonyl-L-phenylalanyl-L-leucine

Chemical Property of BOC-PHE-LEU-OH

Chemical Property:

• Vapor Pressure: 2.1E-15mmHg at 25°C
• Melting Point: 136-138 °C
• Boiling Point: 603.3oC at 760 mmHg
• PKA: 3.49±0.10(Predicted)
• Flash Point: 318.7oC
• PSA: 104.73000
• Density: 1.131g/cm3
• LogP: 3.51970
• Storage Temp.: Store at 0°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-Phe-Leu-OH 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-PHE-LEU-OH

There total 17 articles about BOC-PHE-LEU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate (64152-76-7) → tert-butoxycarbonyl-L-phenylalanyl-L-leucine (33014-68-5)

Guidance literature:

With sodium hydroxide; In methanol; for 1h;

DOI:10.1021/jm00069a001

Reference yield: 78.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine pentafluorophenyl ester (50903-54-3) → tert-butoxycarbonyl-L-phenylalanyl-L-leucine (33014-68-5)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at -5 ℃;

DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine benzyl ester (74193-68-3) → tert-butoxycarbonyl-L-phenylalanyl-L-leucine (33014-68-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.3390/molecules25061451

upstream raw materials:

methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate

L-leucine

N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine pentafluorophenyl ester

(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2-oxo-2-phenyl-ethyl ester

Downstream raw materials:

N--L-phenylalanyl-L-leucyl>-β-D-glucopyranosylamine

Boc-Phe-Leu-Leu-NH₂

Boc-Phe-Leu-Leu-Met-NH₂

Boc-Phe-Leu-NH-CHCONH2