L-Proline beta-naphthylamide hydrochloride

Base Information

• Chemical Name: L-Proline beta-naphthylamide hydrochloride
• CAS No.: 97216-16-5
• Molecular Formula: C₁₅H₁₆N₂O*ClH
• Molecular Weight: 276.766
• Hs Code.: 29339900
• European Community (EC) Number: 624-606-5
• DSSTox Substance ID: DTXSID20584973
• Mol file: 97216-16-5.mol

Synonyms:97216-16-5;L-Proline beta-naphthylamide hydrochloride;169553-07-5;L-Proline-2-naphthylamide hydrochloride;(2S)-N-naphthalen-2-ylpyrrolidine-2-carboxamide;hydrochloride;(2S)-N-(naphthalen-2-yl)pyrrolidine-2-carboxamide hydrochloride;H-Pro-bNA HCl;H-Pro-NA HCl;DTXSID20584973;2-Pyrrolidinecarboxamide,N-2-naphthalenyl-, hydrochloride (1:1);MFCD00038937;AKOS024307515;L-Proline 2-naphthylamide hydrochloride;AS-71666;L-Proline beta -naphthylamide hydrochloride;P-7500;L-Proline beta-naphthylamide hydrochloride, >=99%;N-Naphthalen-2-yl-L-prolinamide--hydrogen chloride (1/1);(S)-N-(naphthalen-2-yl)pyrrolidine-2-carboxamide hydrochloride;2-Pyrrolidinecarboxamide,N-2-naphthalenyl-,hydrochloride(1:1)

Chemical Property of L-Proline beta-naphthylamide hydrochloride

Chemical Property:

• PSA: 41.13000
• LogP: 3.73410
• Storage Temp.: −20°C
• Solubility.: 50% aqueous acetic acid: 50 mg/mL, clear, slightly yellow
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 276.1029409
• Heavy Atom Count: 19
• Complexity: 305

Purity/Quality:

99%, ^*data from raw suppliers

L-Proline-beta-naphthylamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 45
• Safety Statements: 53-45

MSDS Files:

Useful:

• Canonical SMILES: C1CC(NC1)C(=O)NC2=CC3=CC=CC=C3C=C2.Cl
• Isomeric SMILES: C1C[C@H](NC1)C(=O)NC2=CC3=CC=CC=C3C=C2.Cl

Technology Process of L-Proline beta-naphthylamide hydrochloride

There total 2 articles about L-Proline beta-naphthylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-benzyloxycarbonyl-N-(2-naphthyl)-2-pyrrolidinecarboxamide (86925-99-7) → L-proline β-naphthylamide hydrochloride (169553-07-5,97216-16-5)

Guidance literature:

With hydrogenchloride; methanol; palladium; Hydration;

Reference yield:

N-Benzyloxycarbonyl-L-proline (1148-11-4) → L-proline β-naphthylamide hydrochloride (169553-07-5,97216-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; toluene; CHCl₃ / anschliessend Erwaermen mit <2>Naphthylamin

2: palladium; methanol; aqueous HCl / Hydration

With hydrogenchloride; methanol; chloroform; palladium; triethylamine; toluene;

upstream raw materials:

(S)-1-benzyloxycarbonyl-N-(2-naphthyl)-2-pyrrolidinecarboxamide

N-Benzyloxycarbonyl-L-proline