N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

Base Information

Chemical Name:N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide
CAS No.:1416335-58-4
Molecular Formula:C₂₄H₂₃F₃N₆O₄S
Molecular Weight:548.546
Hs Code.:

Synonyms:N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

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Chemical Property of N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

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Technology Process of N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

There total 5 articles about N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.97%

: 1366050-38-5
1,1,1-trifluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide

: 1416336-39-4
6-bromo-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-2-amine

: 1416335-58-4
N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 130 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1416335-58-4
N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2: sodium dithionite / water; tetrahydrofuran / 3.42 h / 20 °C

3: acetonitrile; water; methanol / 2 h

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 130 °C / Microwave irradiation

With sodium dithionite; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 1416335-58-4
N-[5-{2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-1,1,1-trifluoromethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

2: sodium dithionite / water; tetrahydrofuran / 3.42 h / 20 °C

3: acetonitrile; water; methanol / 2 h

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 130 °C / Microwave irradiation

With sodium dithionite; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;