2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 1374021-11-0
• Molecular Formula: C₁₅H₁₄N₂O₂
• Molecular Weight: 254.288
• Mol file: 1374021-11-0.mol

Synonyms:2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 4 articles about 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

anthranilic acid amide (28144-70-9,88-68-6) + ortho-anisaldehyde (135-02-4) → 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1374021-11-0)

Guidance literature:

With (11aS)-3,7-di-9-anthracenyl-10,11,12,13-tetrahydro-5-hydroxy-5-oxide diindeno[7,1de:10,70-fg][1,3,2] dioxaphosphocin; In chloroform; at 20 ℃; for 24h; enantioselective reaction; Molecular sieve;

DOI:10.1021/cs400591u

Reference yield: 71.0%

C18H15NO3S + anthranilic acid amide (28144-70-9,88-68-6) → 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1374021-11-0)

Guidance literature:

With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In chloroform; at -20 ℃; for 96h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201100849

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) + ortho-anisaldehyde (135-02-4) → 2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1374021-11-0) + (R)-2-(2-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:

With (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin; In m-xylene; at 25 ℃; for 12h; Overall yield = 95 percent; enantioselective reaction;

DOI:10.1039/d1ob00070e

upstream raw materials:

anthranilic acid amide

ortho-anisaldehyde