o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Base Information

Chemical Name:o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide
CAS No.:77511-59-2
Molecular Formula:C₅₅H₈₃N₁₁O₁₄S₂
Molecular Weight:1186.46
Hs Code.:

Synonyms:o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

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Technology Process of o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

There total 6 articles about o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 77511-56-9
isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

: 54539-80-9
o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosine N-hydroxysuccinimide ester

: 77511-59-2
o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Guidance literature:: With 1-ethyl-piperidine; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1135/cccc19802714

Reference yield:

: 50571-61-4,7685-67-8
o-nitrobenzenesulphenylleucine

: 77511-59-2
o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 53 percent / dicyclohexylcarbodiimide / dimethylformamide / 1.) -20 deg C, 1 h; 2.) 0 deg C, 8 h; 3.) room temp., overnight.

2: 1.) aq. HCl; 2.) N-ethylpiperidine / 1.) CH₃OH, ether; 2.) DMF, room temperature, 64 h.

3: 1.) HCl; 2.) N-ethylpiperidine / 1.) DMF, ether, room temp.; 2.) DMF_.

4: 96 percent / HCl, NaOH / dimethylformamide; diethyl ether; methanol / 1 h / Ambient temperature

5: 92 percent / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1135/cccc19802714

Reference yield:

: 77511-48-9
o-nitrobenzenesulphenylleucine N-hydroxyphthalimide ester

: 77511-59-2
o-nitrobenzenesulphenyl-O-tert-butyltyrosyl-isoleucyl-leucyl-asparaginyl-S-(γ-carboxypropyl)cysteinyl-prolyl-leucyl-glycinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. HCl; 2.) N-ethylpiperidine / 1.) CH₃OH, ether; 2.) DMF, room temperature, 64 h.

2: 1.) HCl; 2.) N-ethylpiperidine / 1.) DMF, ether, room temp.; 2.) DMF_.

3: 96 percent / HCl, NaOH / dimethylformamide; diethyl ether; methanol / 1 h / Ambient temperature

4: 92 percent / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1135/cccc19802714