N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline

Base Information

• Chemical Name: N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline
• CAS No.: 80548-12-5
• Molecular Formula: C₃₁H₃₂N₂O₇
• Molecular Weight: 544.604
• Mol file: 80548-12-5.mol

Synonyms:N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline

Chemical Property of N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline

There total 1 articles about N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-phthalimidomalonate (5680-61-5) → N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline (80548-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium / ethanol / 0.5 h

2: m-(benzyloxy)aniline hydrochloride, NaBH₃CN / methanol / 48 h / Ambient temperature

With sodium; sodium cyanoborohydride; m-aminophenyl benzyl ether hydrochloride; In methanol; ethanol;

DOI:10.1021/jm00347a005

Reference yield: 95.0%

N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline (80548-12-5) → N-(γ,γ-dicarbethoxy-γ-aminobutyl)-m-(benzyloxy)aniline (736883-74-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1021/jm00347a005

Reference yield:

N-(γ,γ-dicarbethoxy-γ-phthalimidobutyl)-m-(benzyloxy)aniline (80548-12-5) → 2-Amino-5-(3-hydroxy-phenylamino)-pentanoic acid (80548-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / aq. NH₂NH₂ / ethanol / 2 h / Heating

2: 1.) 0.5 N aq. KOH, 2.) aq. HCl / 1.) reflux, 4 h, 2.) reflux, 1.5 h

With hydrogenchloride; potassium hydroxide; hydrazine hydrate; In ethanol;

DOI:10.1021/jm00347a005

upstream raw materials:

diethyl 2-phthalimidomalonate

Downstream raw materials:

N-(γ,γ-dicarbethoxy-γ-aminobutyl)-m-(benzyloxy)aniline

2-Amino-5-(3-hydroxy-phenylamino)-pentanoic acid